Kane has been training with the first team since Tuesday and Nuno Espirito Santo has decided he is fit and focused enough to get involved.
However, the head coach ultimately decided to stick with the same team that beat Manchester City so impressively last Sunday, with Lucas Moura, Heung-min Son and Steven Bergwijn forming an effective trio on the counterattack.
Elsewhere, Giovani Lo Celso and Harry Winks did little against Pacos de Ferreira on Thursday, so Oliver Skipp retains his place in midfield. Tanguy Ndombele – another who wants to leave – will not appear.
Cristian Romero has not traveled and will therefore have to wait for his full Premier League debut.
Other new signing Bryan Gil is also hoping to lose in the Premier League after showing flashes in the Europa Conference League loss.
Centerbacks Cameron Carter-Vickers and Joe Rodon are absent due to injury.
Confirmed team news
Wolves: José Sa, Kilman, Coady, Saiss, Nelson Semedo, Neves, Joao Moutinho, Marcal, Traoré, Trincao, Jimenez
Subscribers: Hoever, Ait Nouri, Silva, Gibbs-White, Ruddy, Dendoncker, Cundle, Marques, Campbell
Tottenham: Lloris, Tanganga, Sanchez, Dier, Reguilon, Skipp, Hojbjerg, Alli, Lucas Moura, Fils, Bergwijn
Subscribers: Doherty, Winks, Kane, Gil, Lo Celso, Sessegnon, Gollini, Davies, Scarlett
When: Sunday August 22, 2 p.m. BST
Spurs squad of: Lloris, Gollini, Doherty, Aurier, Davies, Sessegnon, Reguilon, Dier, Sanchez, Romero, Hojbjerg, Dele, Lo Celso, Winks, Skipp, Sissoko, John, Bergwijn, Gil, Lucas, Kane, Son, Moura, Scarlett, Clarke .
Injured: Rodon (unknown), Carter-Vickers (ankle)